Light-Triggered Graphene/Black Phosphorus Heterostructure FET Platform for Ultrasensitive Detection of Alzheimer’s Disease Biomarkers at the Zeptomole Level
Due to the low concentration of amyloid-beta (Aβ) in plasma and the high content of interfering factors, the conventional detection method for the quantification of Aβ still faces the problem of insufficient limit of detection (LOD). In this work, we propose a new light-triggered graphene-black phosphorus heterostructure (G-BP) field-effect transistor (FET) biosensing platform that achieves a marked reduction in the LOD. The LOD for Alzheimer's disease (AD) biomarker Aβ<sub>42</sub> detection using the G-BP FET is as low as 235.1 zM (2.351 × 10<sup>-19</sup> M), which is the lowest value reported to date and is approximately 2 to 3 orders of magnitude lower than other reported biosensing platforms. The G-BP FET platform provides precise, real-time guidance for non-invasive early diagnosis, disease monitoring, and personalized treatment plans for AD. Moreover, this method has good scalability and potential applications in other areas, including early detection of cancer and other major chronic diseases.
Authors
- Meng Qiu (ORCID: https://orcid.org/0000-0002-0178-3479)
- Xilin Tian
- Ming‐Min Yang (ORCID: https://orcid.org/0000-0002-6628-5112)
- Yi Liu (ORCID: https://orcid.org/0000-0001-9510-9559)
- Yihan Zhu (ORCID: https://orcid.org/0000-0002-8150-7350)
- Yule Zhang
- Qingming Luo
- Liding Zhang (ORCID: https://orcid.org/0000-0001-5782-6549)
- Huide Wang (ORCID: https://orcid.org/0000-0003-0832-4774)
- Ziqian Wang (ORCID: https://orcid.org/0000-0002-0282-5941)
- Han Zhang (ORCID: https://orcid.org/0000-0002-0166-1973)
- Zhi Chen (ORCID: https://orcid.org/0000-0002-7624-3143)
- Ke Jiang (ORCID: https://orcid.org/0000-0002-8372-1473)
- Ning Fan (ORCID: https://orcid.org/0000-0003-1673-911X)
- Tianzhong Li (ORCID: https://orcid.org/0000-0003-4408-0367)
- Dianyuan Fan
- Haiming Luo (ORCID: https://orcid.org/0000-0002-6226-5800)
- Yun Wang (ORCID: https://orcid.org/0009-0006-5841-3627)
- Chen Wang (ORCID: https://orcid.org/0009-0004-4302-2565)
Institutions
- Hangzhou Normal University (CN)
- Shenzhen University (CN)
- Korea University (KR)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Changchun Institute of Optics, Fine Mechanics and Physics (CN)
- Suzhou Institute of Biomedical Engineering and Technology (CN)
- Wuhan National Laboratory for Optoelectronics (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Ocean University of China (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Research
- Published
- 2025-01-01
- DOI
- https://doi.org/10.34133/research.0772
- Citations
- 1
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.81