Effects of obesity‐associated plasma markers on adipose stem cell function and epigenetic regulation
In vitro leptin exposure enhanced CCL2 expression/secretion and increased KDM6A/KDM6B and EP300 transcription, highlighting how obesity-driven epigenetic mechanisms, including leptin-mediated pathways, disrupt ASC plasticity and perpetuate adipose tissue dysfunction, offering novel therapeutic targets for metabolic disease intervention.
Authors
- Jussara de Jesus Simão (ORCID: https://orcid.org/0000-0001-8015-8278)
- Ana Beatriz Marques Abel (ORCID: https://orcid.org/0000-0003-2930-6321)
- Lucia Armelin‐Correa (ORCID: https://orcid.org/0000-0002-7200-5463)
- André Valente Santana (ORCID: https://orcid.org/0000-0002-3886-3261)
- Maria Isabel Cardoso Alonso‐Vale (ORCID: https://orcid.org/0000-0001-5847-8080)
- Mônica Marques Telles (ORCID: https://orcid.org/0000-0003-4342-6688)
- Paula VOLPE (ORCID: https://orcid.org/0000-0002-1586-5037)
- Marília Moraes (ORCID: https://orcid.org/0009-0004-3048-5632)
- Andressa França Sousa Bispo (ORCID: https://orcid.org/0000-0002-7698-710X)
- Victor Tadeu Gonçalves Plata (ORCID: https://orcid.org/0000-0003-0842-1865)
Institutions
- D’Or Institute for Research and Education (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Obesity
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/oby.24321
- Citations
- 5
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo