Clinical and Pathogenetic Relationship Between Nephropathy and Diabetic Foot Syndrome

Diabetic nephropathy and diabetic foot syndrome are among the most severe and disabling complications of diabetes mellitus, determining the severity of systemic disorders and an unfavorable prognosis. Modern research indicates the presence of a common pathogenetic basis for these conditions, including chronic inflammation, endothelial dysfunction, microcirculation disorders and activation of fibrotic processes. In this work, data on 32 patients with various degrees of diabetic foot syndrome according to the Wagner classification, who simultaneously showed signs of diabetic nephropathy, are considered. The analysis showed that more severe forms of foot syndrome are associated with a pronounced decrease in the glomerular filtration rate and a high degree of albuminuria, which indicates progressive kidney damage in this category of patients. The data obtained emphasize the need for a comprehensive assessment of target organ damage in patients with diabetes mellitus, which is important both for the prognosis and for the choice of management tactics. Particular attention is paid to the role of chronic renal failure as a factor in the deterioration of reparative processes and a predisposition to purulent-necrotic complications of the lower extremities.