Flexible Cervical Photodynamic Therapy Device

ABSTRACT Cervical cancer is the fourth most common cancer among women worldwide. It is a malignant tumor that originates from the cervix. Conventional treatments for cervical cancer, such as surgical resection, radiotherapy, and chemotherapy, are invasive and often result in adverse reactions. Photodynamic therapy is a noninvasive local treatment method. Given its fewer side effects, low cost, and short healing time, it is regarded as an alternative method for treating cervical precancerous lesions. We have designed a therapeutic device for both the cervix and cervical vault. This device is primarily composed of a circular light‐emitting diode array as the light source, a cylindrical light guide, and a flexible trumpet‐shaped light homogenizer. The light homogenizer is flexible, cost‐effective, and can be manufactured using a mold. Verification is initially accomplished through Monte Carlo simulation, to explore light transportation within tissues, and then by a physical measurement setup. The results indicate that the irradiance at the output end of the equipment can reach up to 98 mW/cm 2 , with the coefficient of variations along the axis being less than 14.2%, which provides a low‐cost and effective solution for the treatment of cervical cancer and precancerous lesions.