Synthesis of 3,3-Disubstituted Oxindoles through Cascade Alkylarylation of <i>N</i>-Arylacrylamides with Carboxylic Acids Enabled by Iron Photocatalysis
Herein, we developed a cascade alkylarylation reaction of <i>N</i>-arylacrylamides with carboxylic acids to construct 3,3-disubstituted oxindole derivatives. The transformation employs inexpensive iron photocatalysis under visible light irradiation. A broad scope of carboxylic acids and <i>N</i>-arylacrylamides could be well tolerated. Additionally, several synthesized oxindole compounds showed the suppression of nitric oxide generation in LPS-induced RAW 264.7 macrophage cells.
Authors
- Shuxin Yang
- Wanpeng Lu (ORCID: https://orcid.org/0000-0003-3403-667X)
- Jiaxing Lv
- Yi Bi (ORCID: https://orcid.org/0000-0003-0879-0572)
- Xinran Zhang (ORCID: https://orcid.org/0000-0002-0734-6173)
- Xianhe Fang
Institutions
- Yantai University (CN)
- Systèmes avancés de délivrance de principes actifs
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1021/acs.joc.5c00970
- Citations
- 3
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- Yantai University
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China