Blocking Tim-3 enhances CD8 <sup>+</sup> T cell activity to inhibit hepatocellular carcinoma recurrence post-radiofrequency ablation
Tim-3 expression is elevated in CD8<sup>+</sup> T cells within residual tumors after iRFA, which contributed to their accelerated advancement. Anti-αTim-3 slows tumor progression by boosting CD8<sup>+</sup> T cell anti-tumor activity and enhancing response to anti-αPD-1 treatment.
Authors
- Xiaodie Ye (ORCID: https://orcid.org/0000-0001-8447-1907)
- Na Wu (ORCID: https://orcid.org/0000-0002-2654-6605)
- Wei Lu (ORCID: https://orcid.org/0000-0001-5876-0860)
- Weiguo Cai
- Xinru Pei
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- International Journal of Hyperthermia
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1080/02656736.2025.2516502
- Citations
- 2
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.59