Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?
In this study across seven European countries, healthy lifestyle was inversely associated with colon cancer risk, with stronger associations in men than women and no differences across SEP. However, the serum metabolic signatures after adjustment for lifestyle factors were not found to be associated with colon cancer risk, suggesting that lifestyle impacts colon cancer through mechanisms not captured by the signatures.
Authors
- Sébastien Lamy (ORCID: https://orcid.org/0000-0003-3886-1968)
- Komodo Matta (ORCID: https://orcid.org/0000-0002-9769-7769)
- Cyrille Delpierre (ORCID: https://orcid.org/0000-0002-0831-080X)
- Konstantinos K. Tsilidis (ORCID: https://orcid.org/0000-0002-8452-8472)
- Anastasia Chrysovalantou Chatziioannou (ORCID: https://orcid.org/0000-0002-1973-7542)
- Thérèse Truong (ORCID: https://orcid.org/0000-0002-2943-6786)
- Nivonirina Robinot (ORCID: https://orcid.org/0000-0002-2532-1455)
- Agnetha Linn Rostgaard‐Hansen (ORCID: https://orcid.org/0000-0001-5731-1772)
- Mattias Johansson (ORCID: https://orcid.org/0000-0002-3116-5081)
- Pauline Frénoy (ORCID: https://orcid.org/0000-0002-7435-5125)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Rosario Tumino (ORCID: https://orcid.org/0000-0003-2666-414X)
- Fulvio Ricceri (ORCID: https://orcid.org/0000-0001-8749-9737)
- Mario Fordellone (ORCID: https://orcid.org/0000-0003-0790-892X)
- Pekka Keski‐Rahkonen (ORCID: https://orcid.org/0000-0001-9437-3040)
- Salvatore Vaccarella (ORCID: https://orcid.org/0000-0002-2516-2167)
- Chloé Marques (ORCID: https://orcid.org/0000-0003-3203-7310)
- Pietro Ferrari (ORCID: https://orcid.org/0000-0001-9358-7338)
- Sabina Sieri (ORCID: https://orcid.org/0000-0001-5201-172X)
- Renée T. Fortner (ORCID: https://orcid.org/0000-0002-1426-8505)
- Vivian Viallon (ORCID: https://orcid.org/0000-0002-9799-4421)
- Therese Haugdahl Nøst (ORCID: https://orcid.org/0000-0001-6805-3094)
- Elio Ríboli (ORCID: https://orcid.org/0000-0001-6795-6080)
- Kristin Benjaminsen Borch (ORCID: https://orcid.org/0000-0002-1741-2322)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Sandra M. Colorado‐Yohar (ORCID: https://orcid.org/0000-0002-6700-0780)
- Heinz Freisling (ORCID: https://orcid.org/0000-0001-8648-4998)
- Camino Trobajo‐Sanmartín (ORCID: https://orcid.org/0000-0001-5105-252X)
- Rhea Harewood (ORCID: https://orcid.org/0000-0003-4446-2138)
- Christina C. Dahm (ORCID: https://orcid.org/0000-0003-0481-2893)
- Elisabete Weiderpass (ORCID: https://orcid.org/0000-0003-2237-0128)
- Anne Marie Tjønneland (ORCID: https://orcid.org/0000-0003-4385-2097)
- Roland Wedekind (ORCID: https://orcid.org/0000-0003-1364-7666)
- Keren Papier (ORCID: https://orcid.org/0000-0002-4102-6835)
- María‐José Sánchez (ORCID: https://orcid.org/0000-0003-4817-0757)
- Tonje Braaten
- Rudolf Kaaks
- Olatz Mokoroa-Carollo
Institutions
- University of Copenhagen (DK)
- Norwegian Institute of Public Health (NO)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- University of Potsdam (DE)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- German Cancer Research Center (DE)
- University of Ioannina (GR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Aarhus University (DK)
- Norwegian University of Science and Technology (NO)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- Basque Government (ES)
- Levanger Hospital (NO)
- Institut Gustave Roussy (FR)
- Nord University (NO)
- Universidad de Antioquia (CO)
- University of Oxford (GB)
- Instituto de Salud Pública de Navarra (ES)
- Ministry of Health (ES)
- Biogipuzkoa Health Research Institute (ES)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Navarre Institute of Health Research (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Italian Association for Cancer Research (IT)
- Institut Claudius Regaud (FR)
- Cancer Registry of Norway (NO)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Danish Cancer Society (DK)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- German Institute of Human Nutrition (DE)
- Centre international de recherche sur le cancer (FR)
- Imperial College London (GB)
- University of Turin (IT)
- Andalusian School of Public Health (ES)
- UiT The Arctic University of Norway (NO)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s40170-025-00388-0
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centre International de Recherche sur le Cancer
- World Cancer Research Fund
- Rijksinstituut voor Volksgezondheid en Milieu