Characteristics of gut microbiota in high-methylated colorectal cancer
This study characterizes the gut microbiota profile in HMCC and suggests that bacteria, such as F. nucleatum, may contribute to HMCC pathogenesis through DNA methylation. Further studies are needed to determine whether the microbiome acts as a promoter or bystander in HMCC development.
Authors
- Yohei Ozawa (ORCID: https://orcid.org/0000-0002-5136-8281)
- Taiki Kajiwara (ORCID: https://orcid.org/0000-0002-2532-5368)
- Tomoyuki Ono (ORCID: https://orcid.org/0000-0002-2781-5125)
- Takashi Kamei (ORCID: https://orcid.org/0000-0003-1282-0463)
- Hideaki Karasawa (ORCID: https://orcid.org/0000-0003-0358-3398)
- Shinji Fukuda (ORCID: https://orcid.org/0000-0003-0771-1158)
- Fumiyoshi Fujishima (ORCID: https://orcid.org/0000-0001-8400-5551)
- Wakako Ikeda‐Ohtsubo (ORCID: https://orcid.org/0000-0001-8489-1936)
- Chikashi Ishioka
- Shinobu Ohnuma (ORCID: https://orcid.org/0000-0002-0205-8957)
- Takaaki Abe (ORCID: https://orcid.org/0000-0003-3170-4660)
- Atsushi Kohyama (ORCID: https://orcid.org/0000-0001-5807-668X)
- Hideyuki Suzuki (ORCID: https://orcid.org/0000-0003-0323-7196)
- Kota Ouchi (ORCID: https://orcid.org/0000-0002-5572-1337)
- Michiaki Unno (ORCID: https://orcid.org/0000-0002-2145-6416)
- Kazuhiro Watanabe (ORCID: https://orcid.org/0000-0001-8662-9333)
- Tatsushi Saito
Institutions
- University of Tsukuba (JP)
- Tohoku University (JP)
- Keio University (JP)
- Juntendo University (JP)
- Innovation Center of NanoMedicine (JP)
- Tohoku University Hospital (JP)
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- International Journal of Clinical Oncology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s10147-025-02812-3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science