Systematic Pan-Cancer Analysis of the Oncogenic and Immunological Function of Stanniocalcin-1 (STC1)
This multi-modal study establishes STC1 as a novel pan-oncogenic factor with dual roles in tumor progression (via EMT and stemness regulation) and immune microenvironment remodeling. The strong association with immune checkpoints (PD-L1, CTLA4) and T cell infiltration patterns positions STC1 as a promising immunotherapeutic target, particularly in STAD and MSI-high cancers. These findings provide mechanistic insights for developing STC1-directed therapeutic strategies.
Authors
- Long Zhao (ORCID: https://orcid.org/0000-0002-9014-8345)
- Zhidong Gao (ORCID: https://orcid.org/0000-0002-8415-7587)
- Yingjiang Ye (ORCID: https://orcid.org/0000-0002-7904-3163)
- Lin Gan (ORCID: https://orcid.org/0000-0001-6107-663X)
- Changjiang Yang
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University People's Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-06-16
- DOI
- https://doi.org/10.2174/0109298673358794250531003706
- Primary Topic
- Polar Research and Ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00