Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis
This study highlights a critical role for CAFs in mediating resistance to ALK-TKIs by reprogramming lipid metabolism in ALK-rearranged lung cancer cells. It suggests that targeting these metabolic vulnerabilities, particularly through inhibition of lipid metabolism or induction of ferroptosis, could provide a novel therapeutic approach to overcome resistance and improve patient outcomes.
Authors
- Petros Christopoulos (ORCID: https://orcid.org/0000-0002-7966-8980)
- Holger Sültmann (ORCID: https://orcid.org/0000-0002-5257-8600)
- Ann-Kathrin Daum (ORCID: https://orcid.org/0000-0003-1511-8063)
- Lisa Schlicker (ORCID: https://orcid.org/0000-0002-8350-2289)
- Ursula Klingmüller (ORCID: https://orcid.org/0000-0001-9845-3099)
- Marc A. Schneider (ORCID: https://orcid.org/0000-0001-8269-3821)
- Almut Schulze (ORCID: https://orcid.org/0000-0002-8199-6422)
- Thomas Muley (ORCID: https://orcid.org/0000-0002-8141-0604)
- Michael Thomas (ORCID: https://orcid.org/0000-0001-9511-055X)
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s40170-025-00400-7
- Citations
- 6
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11