The Crosstalk Between Immune Activation and Metabolism in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC

A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart, where cardiomyocytes and immune cells undergo metabolic reprogramming, which allows them to deal with decreased availability of nutrients and oxygen. This status can trigger a metabolic crosstalk between immune cells and cardiomyocytes which, depending on the outcome, can either perpetuate the maladaptive remodelling of the heart, or determine an adaptive response. Therefore, the interplay between immune activation and metabolism is gaining recognition as a potential therapeutic framework. On these premises, future studies addressing novel HF treatments should attempt to evaluate the potential therapeutic role of direct metabolic and immunological crosstalk modulation. The aim of the present scientific statement from the Heart Failure Association of the ESC is to summarize the current evidence for the connection between inflammatory and immune activation and metabolic adaptation in the onset and progression of HF, in order to promote future strategies for the development of targeted-disease preventive and therapeutic measures.

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Publication Details

Journal
European Journal of Heart Failure
Published
2025-06-16
DOI
https://doi.org/10.1002/ejhf.3703
Citations
8
Primary Topic
Cardiac Fibrosis and Remodeling
Type
article
Field-Weighted Citation Impact
11.11
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article

The Crosstalk Between Immune Activation and Metabolism in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC

Markus S. Anker, Arantxa González, Basil S. Lewis, Gianluigi Savarese et al.
8 citations
European Journal of Heart Failure
Cardiac Fibrosis and Remodeling
11.11
article

The Crosstalk Between Immune Activation and Metabolism in Heart Failure. A Scientific Statement of the Heart Failure Association of the ESC

Markus S. Anker, Arantxa González, Basil S. Lewis, Gianluigi Savarese, Antoni Bayes-genis A, Pardeep S. Jhund, Sophie Van Linthout, Gabriele G. Schiattarella, B. Daan Westenbrink, Gary D. Lopaschuk, Carlo G. Tocchetti, Davide Stolfo, Ovidiu Chioncel, Stéphane Heymans, Sven Waßmann, Matteo Pagnesi, Peter van Meer, Lars H. Lund, Gabriele Fragasso, Giuseppe M.C. Rosano, Marco Metra
article en
8 citations

Abstract

A better understanding of additional mechanisms of heart failure (HF) progression may allow a different and more complete phenotyping of the disease and identification of novel therapeutic targets. Persistent latent myocardial inflammation/immune activation in HF may represent an attempt to restore tissue homeostasis in the failing heart, where cardiomyocytes and immune cells undergo metabolic reprogramming, which allows them to deal with decreased availability of nutrients and oxygen. This status can trigger a metabolic crosstalk between immune cells and cardiomyocytes which, depending on the outcome, can either perpetuate the maladaptive remodelling of the heart, or determine an adaptive response. Therefore, the interplay between immune activation and metabolism is gaining recognition as a potential therapeutic framework. On these premises, future studies addressing novel HF treatments should attempt to evaluate the potential therapeutic role of direct metabolic and immunological crosstalk modulation. The aim of the present scientific statement from the Heart Failure Association of the ESC is to summarize the current evidence for the connection between inflammatory and immune activation and metabolic adaptation in the onset and progression of HF, in order to promote future strategies for the development of targeted-disease preventive and therapeutic measures.

European Journal of Heart FailureVol. 27(9)
University Medical Center Groningen (NL), Vita-Salute San Raffaele University (IT), University of Alberta (CA), Carol Davila University of Medicine and Pharmacy (RO), University of Groningen (NL), Technion – Israel Institute of Technology (IL), Max Delbrück Center (DE), Maastricht University Medical Centre (NL), Karolinska Institutet (SE), San Raffaele University of Rome (IT), Maastricht University (NL), Stockholm South General Hospital (SE), Centro de Investigación en Red en Enfermedades Cardiovasculares (ES), Surgical Specialties (Canada) (CA), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Deutsches Herzzentrum der Charité (DE), Carmel Medical Center (IL), Federico II University Hospital (IT), Ospedale Santa Maria della Misericordia di Udine (IT), German Centre for Cardiovascular Research (DE), IRCCS Ospedale San Raffaele (IT), Clinica Universidad de Navarra (ES), Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Hospital Universitari Germans Trias i Pujol (ES), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), Charité - Universitätsmedizin Berlin (DE), University of Glasgow (GB), University of Brescia (IT), Universidad de Navarra (ES), Saarland University (DE)
Good health and well-being
Openalex Percentile: Top 1%
Cardiac Fibrosis and Remodeling
11.11
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