Psychological Characteristics of Mothers of Children with Chronic Illnesses: A Focus on Type 1 Diabetes Mellitus

<b>Background:</b> Mothers of children with Type 1 Diabetes Mellitus (T1DM) frequently face high levels of psychological stress. While the impact of this stress on caregiving is well documented, the potential role of spirituality as a protective factor has received limited attention. <b>Objective:</b> This cross-sectional study aimed to assess the relationships among psychological symptoms, spirituality, and coping in mothers caring for children with T1DM, with a particular focus on the potential protective role of spirituality in caregiver resilience. <b>Methods:</b> A total of 134 mothers completed validated Greek versions of the Symptom Checklist-90 (SCL-90) and the Spiritual and Religious Attitudes in Dealing with Illness (SpREUK) questionnaire. Descriptive statistics, Pearson correlations, and multiple linear regression analyses were used to explore associations and predictive relationships. <b>Results:</b> Participants reported elevated psychological symptoms, particularly somatization, anxiety, and depression. Regression analysis revealed that trust in higher guidance was a significant negative predictor of somatization (b = -0.775, <i>p</i> < 0.001), indicating a potential buffering effect. In contrast, the search for support was positively associated with somatization (b = 0.704, <i>p</i> < 0.001), suggesting a more reactive coping pattern. Other spiritual variables, including the total spirituality score and reflection, were not statistically significant in the multivariate model. <b>Conclusions:</b> These findings highlight the relevance of spirituality-particularly spiritual trust-in understanding psychological distress among caregiving mothers. Incorporating existential and spiritual elements into psychosocial interventions may enhance maternal well-being. Longitudinal studies are needed to clarify spirituality's role as a protective or mediating factor in chronic caregiving contexts.