Electrochemical site-selective C(sp<sup>3</sup>)–H amination of alkyl substituted indoles and pyrroles
Precise cleavage of a C(sp<sup>3</sup>)-H bond among multi-C(sp<sup>3</sup>)-H bonds with similar properties is highly valuable yet remains challenging. Herein, we develop an electrochemical site-selective C(sp<sup>3</sup>)-H amination of C2-methyl/ethyl indoles and pyrroles, achieving moderate-to-high yields without the need for external oxidants or metal catalysts. The reaction exhibits excellent regioselectivity and broad substrate compatibility.
Authors
- Xiaoyu Sheng
- Yanqi Ge (ORCID: https://orcid.org/0000-0003-1627-2951)
- Xu Cheng (ORCID: https://orcid.org/0000-0001-6218-611X)
- Qiong Wu (ORCID: https://orcid.org/0000-0003-1312-6385)
- Weijie Ding (ORCID: https://orcid.org/0000-0003-0668-4602)
- Shuai Liu (ORCID: https://orcid.org/0009-0008-7183-4842)
- Jianan Li (ORCID: https://orcid.org/0000-0001-8398-4962)
- Tianshu Zhang (ORCID: https://orcid.org/0009-0002-4870-5416)
Institutions
- Xuzhou University of Technology (CN)
- Taizhou University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02009c
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Jiangsu Province
- Natural Science Research of Jiangsu Higher Education Institutions of China