Oral formulations for cannabidiol: Improved absolute oral bioavailability of biodegradable cannabidiol self-emulsifying drug delivery systems
These findings underscore the potential of SEDDS as an effective oral delivery system for CBD, capable of achieving higher CBD plasma concentrations than Epidiolex. Additionally, the biodegradable PG-based SEDDS demonstrated improved absolute bioavailability compared to Epidiolex, emphasizing the importance of formulation design in optimizing oral drug delivery systems.
Authors
- Gitte Nykjær Nikolajsen
- Kathrine Kjær (ORCID: https://orcid.org/0000-0002-2367-2470)
- Astri Purwanti
- Andreas Bernkop‐Schnürch (ORCID: https://orcid.org/0000-0003-4187-8277)
- Matthias Sandmeier (ORCID: https://orcid.org/0000-0002-6988-8015)
- Sanne Jensen (ORCID: https://orcid.org/0000-0002-8095-2700)
- Ee Tsin Wong (ORCID: https://orcid.org/0000-0003-0967-1305)
- Julia Hoeng (ORCID: https://orcid.org/0000-0001-5371-6801)
- Wenhao Xia (ORCID: https://orcid.org/0000-0003-3087-5441)
- Heidi Ziegler Bruun
- Sera Lindner
Institutions
- Novartis (Switzerland) (CH)
- Universität Innsbruck (AT)
- Fertin Pharma (Denmark) (DK)
- Ferro (United States) (US)
Publication Details
- Journal
- Colloids and Surfaces B Biointerfaces
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.colsurfb.2025.114879
- Citations
- 7
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 9.76