Clinical and Cognitive Profiles of Individuals with Alzheimer's Disease and Comorbid Seizures
Comorbid AD and seizures are associated with distinct cognitive and clinical profiles, greater vascular disease burden, and more severe dementia. Findings emphasize the need for early seizure detection, comprehensive cognitive evaluations, and research on cerebrovascular contributions to inform targeted interventions. ANN NEUROL 2025;98:533-546.
Authors
- Bruce P. Hermann (ORCID: https://orcid.org/0000-0003-0133-4427)
- Anny Reyes (ORCID: https://orcid.org/0000-0003-0625-6990)
- Ifrah Zawar (ORCID: https://orcid.org/0000-0002-6103-4250)
- Rani A. Sarkis (ORCID: https://orcid.org/0000-0001-8291-7864)
- Robyn M. Busch (ORCID: https://orcid.org/0000-0002-5442-4912)
- Mark W. Bondi (ORCID: https://orcid.org/0000-0002-1742-3451)
- Carrie R. McDonald (ORCID: https://orcid.org/0000-0002-0721-5640)
- Jaideep Kapur (ORCID: https://orcid.org/0000-0002-8608-1352)
- Vineet Punia (ORCID: https://orcid.org/0000-0002-0552-6736)
- David P. Salmon (ORCID: https://orcid.org/0000-0003-4533-4090)
Institutions
- Brigham and Women's Hospital (US)
- Allen Institute for Brain Science (US)
- Cleveland Clinic (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- University of California San Diego (US)
- University of Wisconsin Health (US)
- Wisconsin Division of Public Health (US)
- University of Virginia (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/ana.27284
- Citations
- 3
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Burroughs Wellcome Fund
- Alzheimer's Association
- American Epilepsy Society
- National Academy of Neuropsychology