Markers of Kidney Tubule Secretion and Future Risk of Sepsis-Associated Acute Kidney Injury Among REGARDS Participants
Kidney tubular secretion eliminates many endogenous and exogenous substances that are not eliminated or are only partially eliminated by glomerular filtration.1 Endogenous secreted solutes have facilitated the assessment of tubular secretion using simple paired blood and urine samples.1 Prior studies have demonstrated that reduced tubule secretion is associated with risk of chronic kidney disease (CKD) progression.2
Authors
- Jesse C. Seegmiller (ORCID: https://orcid.org/0000-0003-2542-6502)
- Henry E. Wang (ORCID: https://orcid.org/0000-0002-4738-0093)
- Pranav Sandilya Garimella (ORCID: https://orcid.org/0000-0002-6016-4715)
- Edward D. Siew (ORCID: https://orcid.org/0000-0003-1343-8784)
- Alexander L. Bullen (ORCID: https://orcid.org/0000-0001-6864-0336)
- Feli Guerrero
- Orlando M. Gutiérrez (ORCID: https://orcid.org/0000-0001-6593-3571)
- Byron C. Jaeger (ORCID: https://orcid.org/0000-0001-7399-2299)
- Ashutosh Tamhane (ORCID: https://orcid.org/0000-0002-4475-2760)
- Michael G. Shlipak (ORCID: https://orcid.org/0000-0002-9559-204X)
- Dena E. Rifkin (ORCID: https://orcid.org/0000-0002-1278-5795)
- Joseph Vincent Bonventre (ORCID: https://orcid.org/0000-0001-7144-386X)
- Simon B. Ascher
- Joachim H Ix
Institutions
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Harvard University (US)
- Oakland University (US)
- Kidney Research UK (GB)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- VA Tennessee Valley Healthcare System (US)
- Tennessee Department of Health (US)
- Wake Forest University (US)
- The Ohio State University (US)
- University of California, Davis (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.xkme.2025.101044
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00