Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Our findings suggest that circulating plasma aSyn strains may impact LBD clinical presentation, particularly cognition. The enrichment of these aSyn species in plasma but not CSF also suggests a potential source outside the brain. ANN NEUROL 2025;98:682-698.
Authors
- George T. Kannarkat (ORCID: https://orcid.org/0000-0003-4428-1820)
- Katherine Dorfman (ORCID: https://orcid.org/0000-0002-2022-2490)
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Rebecca Zack (ORCID: https://orcid.org/0009-0001-6969-9193)
- Kelvin C. Luk (ORCID: https://orcid.org/0000-0002-6591-6269)
- Thomas Francis Tropea (ORCID: https://orcid.org/0000-0003-0766-1496)
- Daniel A. Weintraub (ORCID: https://orcid.org/0000-0003-0633-7168)
- Roseanne Davila‐Rivera
- James F. Morley (ORCID: https://orcid.org/0000-0002-1950-9128)
- Sharon Xiangwen Xie (ORCID: https://orcid.org/0000-0002-7886-4103)
- Alice Chen‐Plotkin (ORCID: https://orcid.org/0000-0002-3387-2038)
- Edward B. Lee (ORCID: https://orcid.org/0000-0002-4589-1180)
- Sanaz Arezoumandan (ORCID: https://orcid.org/0000-0001-6569-9009)
- Virginia M.‐Y. Lee (ORCID: https://orcid.org/0000-0003-3536-6902)
- David J. Irwin (ORCID: https://orcid.org/0000-0002-5599-5098)
- R. Tyler Skrinak
- Rizwan Akhtar
- Ganesh Chandrasekaran (ORCID: https://orcid.org/0009-0008-6161-6921)
Institutions
- Northwestern University (US)
- Philadelphia VA Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/ana.27288
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Alzheimer's Association
- American Heart Association
- Children's Hospital of Philadelphia
- University of Pennsylvania
- Demensförbundet
- Weston Brain Institute
- National Institutes of Health
- Parkinsonfonden