NR4A1 Alleviates Subretinal Fibrosis by Inhibiting Macrophage to Myofibroblast Transition
NR4A1 inhibits MMT and reduces ECM deposition in SF. Its agonist Csn-B inhibits MMT by inhibiting AKT-induced NR4A1 phosphorylation, which then attenuates SF.
Authors
- Rufei Yang
- Rui Wang (ORCID: https://orcid.org/0000-0003-1723-4746)
- Ning Wang (ORCID: https://orcid.org/0000-0002-6344-9716)
- Ying Su (ORCID: https://orcid.org/0000-0003-3952-7216)
- Tingting Zong
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1167/iovs.66.6.47
- Citations
- 2
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.82