Calcium-Dependent Regulation of Desmosomal Proteins in Human Meibomian Gland Epithelial Cells
Our study demonstrates the impact of calcium concentration on the expression and localization of desmosomal proteins and their role in meibocyte differentiation in both human and mouse models. To further understand the physiological mechanisms of desmosomes in the meibomian gland and the pathophysiology of MGD, further research into desmosomal functionality is required, which may pave the way for novel therapeutic strategies for evaporative dry eye disease.
Authors
- Martin Schicht (ORCID: https://orcid.org/0000-0001-5155-5477)
- Fabian Garreis
- Ulrike Hampel (ORCID: https://orcid.org/0000-0001-7562-0421)
- Friedrich Paulsen (ORCID: https://orcid.org/0000-0002-0527-0953)
- Susanne Adelung
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- University Hospital Leipzig (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1167/iovs.66.6.49
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00