Independent validation and outlier analysis of EuroPOND Alzheimer’s disease staging model using ADNI and real-world clinical data
This study highlights the generalizability of EuroPOND's AD EBM model across research and real-world clinical datasets, supporting its use in multi-center trials. aMCI subjects generally reside in more advanced stages than naMCI, who may not necessarily have AD, demonstrating utility for precision recruitment/screening.
Authors
- Christine Bastin (ORCID: https://orcid.org/0000-0002-4556-9490)
- Arne Brys
- Éric Salmon (ORCID: https://orcid.org/0000-0003-2520-9241)
- Olivier Deryck (ORCID: https://orcid.org/0000-0001-6720-5404)
- Adrian Ivanoiu
- Daniel C. Alexander (ORCID: https://orcid.org/0000-0003-2439-350X)
- Mandy Melissa Jane Wittens (ORCID: https://orcid.org/0000-0001-5253-3106)
- Gaëtane Picard
- Sebastiaan Engelborghs (ORCID: https://orcid.org/0000-0003-0304-9785)
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Hanne Struyfs
- Maria Bjerke (ORCID: https://orcid.org/0000-0002-9575-6462)
- Jos Tournoy (ORCID: https://orcid.org/0000-0002-0265-9154)
- Ellen De Roeck (ORCID: https://orcid.org/0000-0002-6566-6562)
- Kurt Segers (ORCID: https://orcid.org/0000-0003-1230-5779)
- Florence Benoit (ORCID: https://orcid.org/0000-0002-8088-551X)
- Jan Versijpt (ORCID: https://orcid.org/0000-0002-8710-5715)
- Bruno Bergmans (ORCID: https://orcid.org/0000-0002-1463-8262)
- Neil P. Oxtoby (ORCID: https://orcid.org/0000-0003-0203-3909)
- Annemie Ribbens (ORCID: https://orcid.org/0000-0002-5732-5389)
- Anne Sieben (ORCID: https://orcid.org/0000-0003-1278-6605)
- Diana M. Sima (ORCID: https://orcid.org/0000-0002-0118-2905)
- Ellis Niemantsverdriet (ORCID: https://orcid.org/0000-0002-5781-3817)
- Dirk Smeets (ORCID: https://orcid.org/0000-0003-1153-094X)
- Maura Bellio
- Peter Paul De Deyn
- Evert Thiery
- Anne‐Marie Van Binst
- Jean‐Christophe Bier
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Université Libre de Bruxelles (BE)
- University Medical Center Groningen (NL)
- Vrije Universiteit Brussel (BE)
- University of Antwerp (BE)
- University of Liège (BE)
- University of Groningen (NL)
- Fund for Scientific Research (BE)
- Universitair Ziekenhuis Leuven (BE)
- Ghent University Hospital (BE)
- Clinique Saint Pierre (BE)
- Antwerp University Hospital (BE)
- Centre Hospitalier Universitaire Brugmann (BE)
- AZ Sint-Jan (BE)
- Universitair Ziekenhuis Brussel (BE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- The Memory Clinic (US)
- Institute of Neurobiology (BG)
- Icometrix (Belgium) (BE)
- AZ Sint-Lucas (BE)
- University College London (GB)
- UCLouvain (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13195-025-01788-6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agentschap Innoveren en Ondernemen
- European Commission
- Agentschap voor Innovatie door Wetenschap en Technologie
- Université de Liège
- Vlaamse regering
- European Regional Development Fund
- Interreg