Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progression
Our study offers innovative perspectives on comprehending the heterogeneity within TME of TNBC, thereby facilitating the elucidation of TNBC biology and providing clinical recommendations for TNBC patients' prognosis, such as IL32<sup>high</sup> Treg infiltration, MCI evaluation, and UQCRFS1 expression.
Authors
- Yitian Chen (ORCID: https://orcid.org/0000-0001-5259-251X)
- Jindong Xie (ORCID: https://orcid.org/0000-0002-2482-7358)
- Yuhui Tang (ORCID: https://orcid.org/0009-0001-2181-4068)
- Zhongbiao Xu
- Aiqi Xu
- Shasha Du (ORCID: https://orcid.org/0000-0002-2650-7286)
- Wei Huang (ORCID: https://orcid.org/0000-0002-3169-5031)
- Lu Yang (ORCID: https://orcid.org/0009-0003-8948-1882)
- Liulu Zhang
- Kun Wang (ORCID: https://orcid.org/0009-0006-7995-3796)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s40164-025-00672-1
- Citations
- 4
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China