Reducing Contrast-Induced Nephropathy Risk in a Murine Model: Role of Avanafil and Vardenafil in Modulating Oxidant/Antioxidant Balance
The treatment groups with VAR, AVA, and NAC were noted with higher values of TAC, CAT, and GSH, while lower values of TBARS and PROTC indicated a protective effect against oxidative injury. The findings indicate that VAR and AVA effectively control the oxidant/antioxidant status, preventing oxidative stress and the incidence of CIN. Further research would be required to replicate these findings and identify the therapeutic potential of VAR and AVA in clinical conditions.
Authors
- Anca Oana Docea (ORCID: https://orcid.org/0000-0002-8162-5955)
- Ioannis-Erineos Zisis
- Ana Maria Bugă (ORCID: https://orcid.org/0000-0003-0082-6956)
- Charalampos Mavridis (ORCID: https://orcid.org/0000-0002-0480-7499)
- Aristidis Tsatsakis (ORCID: https://orcid.org/0000-0003-3824-2462)
- Charalampos Mamoulakis
Institutions
- University of Crete (GR)
- University of Medicine and Pharmacy of Craiova (RO)
- University Hospital of Heraklion (GR)
- University of Craiova (RO)
Publication Details
- Journal
- Cureus
- Published
- 2025-06-16
- DOI
- https://doi.org/10.7759/cureus.86136
- Citations
- 1
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- University of Crete