SREBF1 mediates immunoparalysis of dendritic cells in sepsis by regulating lipid metabolism and endoplasmic reticulum stress
Our study identifies SREBF1 as a central regulator of sepsis-induced DC immunoparalysis by coupling lipid metabolic reprogramming to ER stress activation. Targeting this SREBF1-lipid-ER stress axis represents a novel strategy to reverse immunosuppression in septic patients.
Authors
- Yan Li (ORCID: https://orcid.org/0000-0002-5837-2937)
- Yaolu Zhang (ORCID: https://orcid.org/0000-0003-2955-1386)
- Lingyu Zhu (ORCID: https://orcid.org/0000-0002-0379-4059)
- Fangfang Wu (ORCID: https://orcid.org/0000-0002-1888-4516)
- Jiaxin Liu (ORCID: https://orcid.org/0000-0002-7048-1992)
- Min Zhang (ORCID: https://orcid.org/0000-0002-1165-7839)
- Zhongqiu Lu (ORCID: https://orcid.org/0000-0002-0569-4182)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s12964-025-02295-9
- Citations
- 4
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- Wenzhou Medical University
- National Natural Science Foundation of China
- Wu Jieping Medical Foundation