BioBone – A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed fracture healing – study design
The BioBone study will validate the suitability of CD8 + TEMRA cells as a prognostic marker for impaired fracture healing and their integration into routine clinical practice. The results could have a global impact by incorporating immune-based prognostic tools into clinical workflows, paving the way for precision medicine approaches in trauma care. The BioBone study is funded by the German Federal Ministry of Education and Research (BMBF).
Authors
- Sven Geißler (ORCID: https://orcid.org/0000-0002-8750-6324)
- Michael Dahne
- Richard Stange (ORCID: https://orcid.org/0000-0003-0807-3151)
- Georg Osterhoff (ORCID: https://orcid.org/0000-0001-5051-0998)
- Christian Kleber (ORCID: https://orcid.org/0000-0002-0231-5116)
- Georg Matziolis (ORCID: https://orcid.org/0000-0002-5105-5875)
- Andrea Bauer (ORCID: https://orcid.org/0000-0002-4411-3088)
- Michael J. Raschke (ORCID: https://orcid.org/0000-0002-0265-8098)
- Frederik Maximilian Schäfer
- Hans‐Dieter Volk (ORCID: https://orcid.org/0000-0002-7743-6668)
- Klaus‐Dieter Schaser (ORCID: https://orcid.org/0000-0002-8492-5646)
- H. Wéber (ORCID: https://orcid.org/0000-0002-7584-8044)
- Sven Märdian (ORCID: https://orcid.org/0000-0003-4220-2797)
- Georg N. Duda (ORCID: https://orcid.org/0000-0001-7605-3908)
- Ulrich Stöckle (ORCID: https://orcid.org/0000-0002-6419-2203)
- Maik Stiehler (ORCID: https://orcid.org/0000-0003-4168-7577)
- Simon Reinke (ORCID: https://orcid.org/0000-0002-3451-9383)
- Sebastian Rohe (ORCID: https://orcid.org/0000-0003-0015-9209)
- Denis Gümbel (ORCID: https://orcid.org/0000-0003-1330-2676)
- Carsten Perka
- Philipp Schwabe
Institutions
- Humboldt-Universität zu Berlin (DE)
- Waldkrankenhaus Rudolf Elle (DE)
- Hanseatic University Rostock (DE)
- University Hospital Münster (DE)
- Unfallkrankenhaus Berlin (DE)
- Vivantes Klinikum (DE)
- University Hospital Leipzig (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- BG Klinikum Bergmannstrost Halle (DE)
- University Hospital Carl Gustav Carus (DE)
- Klinik und Poliklinik für Psychotherapie und Psychosomatik (DE)
- University of Rostock (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13018-025-05987-7
- Citations
- 2
- Primary Topic
- Bone fractures and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Charité – Universitätsmedizin Berlin
- Universität Leipzig
- Berlin Institute of Health