Continuous Intravenous Infusion of Hepatocyte Growth Factor Promotes the Development of a Fibrolytic Phenotype in Hepatic Macrophages and Stellate Cells in a Rat Model of Bile Duct Ligation
Continuous intravenous infusion of HGF attenuated BDL-induced liver fibrosis by decreasing IL-6 expression, increasing MMP-2 expression in macrophages and hepatic stellate cells, and inactivating hepatic stellate cells directly or indirectly. These findings offer valuable insights into developing novel HGF-based therapies for liver cirrhosis.
Authors
- Seiichi Mawatari (ORCID: https://orcid.org/0000-0002-3847-1065)
- Shuji Kanmura (ORCID: https://orcid.org/0000-0002-6625-4180)
- Keisuke Yano (ORCID: https://orcid.org/0000-0003-0417-3104)
- Haruka Sakae
- Yuko Nakamura (ORCID: https://orcid.org/0000-0003-3128-4731)
- Sho Ijuin
- Oki Taniyama
- Miho Uehara
- Ai Toyodome
- Kotaro Kumagai (ORCID: https://orcid.org/0000-0001-9532-7580)
- Kazuaki Tabu
- Satoshi Ieiri (ORCID: https://orcid.org/0000-0002-1250-093X)
- Kohei Oda
- Kanji Meguro
- Hiromi Eguchi
- Akio Ido
Institutions
- Kagoshima University (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1111/hepr.14227
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development