Switchable Reaction of <i>p</i> ‐Toluenesulfonyl Hydrazide With <i>N</i> ‐Heteroaryl Ketones: Base‐Controlled Selective Synthesis of <i>N</i> ‐Heteroaryl Alcohols and [1, 2, 3]‐Triazoloheteroarenes
Abstract A novel switchable reaction of p ‐toluenesulfonyl hydrazide with N ‐heteroaryl ketones has been developed to synthesize N ‐heteroaryl alcohols and [1, 2, 3]‐triazoloheteroarenes. p ‐Toluenesulfonyl hydrazide was found to be an efficient reducing agent for N ‐heteroaryl ketones in the presence of Et 3 N. A cascade cyclization reaction occurred when NaOH was applied as a base.
Authors
- Feiyue Hao (ORCID: https://orcid.org/0000-0003-3557-9991)
- Rurong Yu (ORCID: https://orcid.org/0000-0001-5663-9258)
- Jiashou Wu (ORCID: https://orcid.org/0000-0003-4459-1511)
- Zhengneng Jin
- Yifei Wu (ORCID: https://orcid.org/0000-0002-1236-9273)
Institutions
- Taizhou University (CN)
Publication Details
- Journal
- Asian Journal of Organic Chemistry
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1002/ajoc.202500408
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94