Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization
GAPDH originating in L. johnsonii-derived EVs alleviates colitis and improves intestinal barrier by inhibiting STAT3 in macrophages. EVs created from L. johnsonii are a potential novel treatment strategy for UC.
Authors
- Hong Wei (ORCID: https://orcid.org/0000-0001-6069-1067)
- Feng Zhu (ORCID: https://orcid.org/0000-0002-0831-4923)
- Mengzhen Song
- Jinping Fan (ORCID: https://orcid.org/0000-0003-4313-1871)
- Tengfei Lv
- Shiyu Tao
Institutions
- Huazhong Agricultural University (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.jare.2025.06.035
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China