Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway
This study elucidates that Kisspeptin secreted by hypothalamic participates in MG pathogenesis through the Kisspeptin-GPR54-NF-κB signaling axis by regulating CD4<sup>+</sup> T cell subset balance, suggesting that the kisspeptin/GPR54 pathway may serve as a potential therapeutic target for MG treatment.
Authors
- Wenjun Que (ORCID: https://orcid.org/0000-0002-4012-6375)
- Linqi Liu (ORCID: https://orcid.org/0009-0006-6525-1531)
- Rui Fan (ORCID: https://orcid.org/0000-0003-2593-6596)
- Pingyang Ke
- Fei Xiao (ORCID: https://orcid.org/0000-0002-5981-2922)
- Dan Lu
- Jing Dong
- Yaoqi Gan
Institutions
- Ministry of Education (TH)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s12974-025-03486-4
- Citations
- 5
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 6.95
Funders
- Chongqing Medical University