Blastemia portrays a poor prognosis in acute leukemia patients with invasive pulmonary aspergillosis
Blastemia is common in contemporary leukemia patients with IPA and is a significant risk factor for poor IPA outcomes, possibly due to interference with fungal clearance by immune cells. Therefore, blastemia should be considered as a risk stratification parameter in future mycology trials and as an experimental variable in preclinical IPA models.
Authors
- Takahiro Matsuo (ORCID: https://orcid.org/0000-0001-9389-0628)
- Ying Jiang (ORCID: https://orcid.org/0000-0002-1309-9922)
- Hui Yang (ORCID: https://orcid.org/0000-0002-6125-5985)
- Sebastian Wurster (ORCID: https://orcid.org/0000-0002-7784-7256)
- Dimitrios P. Kontoyiannis (ORCID: https://orcid.org/0000-0002-8051-2940)
- Alexandre Bazinet (ORCID: https://orcid.org/0000-0001-5538-4943)
- Sung‐Yeon Cho (ORCID: https://orcid.org/0000-0001-5392-3405)
- Russell E. Lewis (ORCID: https://orcid.org/0000-0002-2002-4339)
- Guillermo Garcia-Manero
- Nathaniel D. Albert
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- University of Padua (IT)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.jinf.2025.106535
- Citations
- 2
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- National Institutes of Health
- University of Texas MD Anderson Cancer Center
- National Institute of Allergy and Infectious Diseases