Dopamine-modified halloysite as new anticancer drug carrier system

A new anticancer drug carrir system based on polydopamine-functionalized halloysite (PDA-HNT) was developed. Hansen solubility parameters were used to select 5-fluorouracil (5-FU) as an anticancer drug. The obtained system was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and nuclear magnetic resonance (1H NMR, 19F-NMR). It was shown that PDA-HNT may be a promising drug nanocarrierfor delivery systems in cancer therapy.