HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction
This study indicated that the gut microecological mechanism of FSN might be associated with its herbal components, which regulate gut microbiota diversity, restore the intestinal barrier, and boost microbial metabolite production. Furthermore, butyrate was observed to modulate intestinal mucosa, inhibit inflammatory responses, repair the intestinal barrier, and mitigate joint damage, thus alleviating RA symptoms.
Authors
- Yanmiao Ma
- Tao Peng (ORCID: https://orcid.org/0000-0001-6133-7078)
- Biwang Liu
- Zhuanzhuan Zhang
- Hao Yuan (ORCID: https://orcid.org/0000-0002-1588-0587)
- Mingyang Li (ORCID: https://orcid.org/0000-0002-9782-3235)
- Ya Wen (ORCID: https://orcid.org/0009-0001-8036-1628)
- Xiuhong Wei
- Jiehao Peng
- Yonghui Wang (ORCID: https://orcid.org/0000-0002-0262-2431)
Institutions
- Shanghai University (CN)
- Shanxi Medical University (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- First Hospital of Shanxi Medical University (CN)
- Shanxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.phymed.2025.156976
- Citations
- 9
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 7.25