Drug repositioning for pan-cancers of the digestive system: Identification of amonafide and BX795 as potential therapeutics via integrative Omics analysis
Our study demonstrates the utility of drug repositioning for identifying potential therapeutics for digestive system cancers. Amonafide and BX795 emerged as promising candidates in targeting both CRC and LIHC. Further in vivo studies and clinical trials are warranted to validate these findings.
Authors
- Buhe Nashun (ORCID: https://orcid.org/0000-0003-1276-6436)
- Fei Gao (ORCID: https://orcid.org/0000-0002-8026-879X)
- Shuqiang Ren (ORCID: https://orcid.org/0009-0006-1300-2592)
- Jiaying Gao (ORCID: https://orcid.org/0000-0002-5237-9548)
- Weidong Liu (ORCID: https://orcid.org/0000-0002-3331-2356)
Institutions
- Inner Mongolia University (CN)
- Agricultural Genomics Institute at Shenzhen (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1371/journal.pone.0325700
- Primary Topic
- Bioinformatics and Genomic Networks
- Type
- article
- Field-Weighted Citation Impact
- 0.00