Integrative analysis of bulk and single-cell gene expression profiles to identify bone marrow mesenchymal cell heterogeneity and prognostic significance in multiple myeloma
Our findings reveal that the proportion of osteogenic MSCs, which are crucial for bone health, decreases as the disease progresses, which is correlated with the bone lysis commonly observed in advanced multiple myeloma. Additionally, immune regulatory MSCs contribute to the formation of an immunosuppressive microenvironment, promoting tumor immune evasion. A prognostic model based on HMGhMSC subpopulations was developed, which demonstrated that these cells have significant potential as therapeutic targets for improving the prognosis and developing treatments for bone disease in multiple myeloma patients.
Authors
- Xing‐Ding Zhang (ORCID: https://orcid.org/0000-0002-2759-5185)
- Jincheng Zeng (ORCID: https://orcid.org/0000-0001-6196-3917)
- Yingmin Liang (ORCID: https://orcid.org/0000-0002-0236-1390)
- Wei Liang (ORCID: https://orcid.org/0009-0006-4003-8590)
- Ziyi Yang (ORCID: https://orcid.org/0000-0001-5883-9552)
- Fei‐er Ju
- Lin Qi (ORCID: https://orcid.org/0000-0003-4005-1702)
- Shu‐Na Chen (ORCID: https://orcid.org/0000-0002-0051-0153)
- Bo Zou (ORCID: https://orcid.org/0000-0002-3215-1255)
- Hao Wu (ORCID: https://orcid.org/0000-0001-6154-9759)
- Jin-Heng Wang
- Zhaoxia Dong
- Zi‐xuan Liu
- Xiaoyan Sang (ORCID: https://orcid.org/0009-0006-2023-2513)
- Yuelan Liang
- Beihui Huang (ORCID: https://orcid.org/0000-0003-2804-4913)
- Juan Li (ORCID: https://orcid.org/0000-0002-0909-4731)
- Zixuan Zhang (ORCID: https://orcid.org/0000-0002-3894-3704)
- Huan Liu (ORCID: https://orcid.org/0000-0001-6223-7677)
- Yongjiang Zheng (ORCID: https://orcid.org/0000-0003-0200-9749)
- Xue‐Qi Liu (ORCID: https://orcid.org/0000-0002-8295-032X)
- Liyuan Zheng (ORCID: https://orcid.org/0000-0001-5041-244X)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Xiamen University (CN)
- Key Laboratory of Guangdong Province (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s12967-025-06637-6
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province