TBpore cluster: A novel phylogenetic pipeline for tuberculosis transmission studies using nanopore next-generation sequencing data
ONT sequencing and the TBpore pipeline offer an accurate alternative to Illumina technology for TB molecular epidemiology. This study suggests potential increased clustering sensitivity with Nanopore technology, warranting further validation on larger datasets with robust epidemiological metadata.
Authors
- Simon Grandjean Lapierre (ORCID: https://orcid.org/0000-0003-3646-1573)
- Hafid Soualhine (ORCID: https://orcid.org/0000-0002-5526-6741)
- Floriane Point (ORCID: https://orcid.org/0000-0002-8757-2049)
- Emmanuelle S. Ametepe (ORCID: https://orcid.org/0000-0002-4400-8851)
- Michael B. Hall (ORCID: https://orcid.org/0000-0003-3683-6208)
- Paul Rivest
- Pierre‐Marie Akochy
- Zamin Iqbal (ORCID: https://orcid.org/0000-0001-8466-7547)
- William Cloutier Charette
- Arpita Chakravarti (ORCID: https://orcid.org/0000-0003-1671-8247)
- Sophie Gagnon
Institutions
- European Bioinformatics Institute (GB)
- Institut National de Santé Publique du Québec (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1371/journal.pone.0325914
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds de Recherche du Québec - Santé