Mass spectrometry-based discovery and diagnostic validation of T. cruzi antigens in the urine of congenitally infected Chagas Disease patients
Our work suggests that it is possible to detect Trypanosoma cruzi infection directly from a noninvasively collected fluid such as urine. A direct test in urine with this success rate would be well suited for rapid diagnosis in low-resource areas. Further studies to validate this approach are warranted.
Authors
- Alessandra Luchini (ORCID: https://orcid.org/0000-0003-1599-0214)
- Manuela Verástegui (ORCID: https://orcid.org/0000-0002-7500-1353)
- Freddy Tinajeros (ORCID: https://orcid.org/0000-0002-5894-2637)
- Edith Málaga (ORCID: https://orcid.org/0000-0002-0075-6655)
- Raghad Almofeez
- María del Carmen Menduiña
- Hannah Steinberg (ORCID: https://orcid.org/0000-0002-3841-6154)
- Amanda Haymond (ORCID: https://orcid.org/0000-0002-9553-275X)
- Lance A. Liotta (ORCID: https://orcid.org/0000-0001-5155-7907)
- Jessica Roman (ORCID: https://orcid.org/0000-0003-0454-1974)
- Ahana Byne
- José Luis Ramírez (ORCID: https://orcid.org/0000-0003-1447-2941)
- Robert H. Gilman
- Kathryn Cassels
Institutions
- Johns Hopkins University (US)
- George Mason University (US)
- Universidad Peruana Cayetano Heredia (PE)
- University of Illinois Chicago (US)
- Prisma (PE)
- Instituto de Estudios Avanzados (VE)
- Ministerio de Salud (BO)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1371/journal.pntd.0013082
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health