BKPyV-specific T-cell Exhaustion in Kidney Transplant Recipients: Targeting Inhibitory Receptors Improves Their Functionality
Sustained BKPyV DNAemia was associated with an exhausted phenotype of BKPyV-specific T cells despite immunosuppression reduction in kidney transplant recipients. We show that anti-BKPyV-specific CD8 functions can be restored ex vivo by blocking the PD1 and TIM3 pathways, paving the way for new treatment strategies.
Authors
- Yassine Taoufik
- Manon Dekeyser (ORCID: https://orcid.org/0000-0002-1829-3767)
- Ivan Scriabine (ORCID: https://orcid.org/0000-0003-0125-5956)
- Karen Bargiel
- Antoine Dürrbach (ORCID: https://orcid.org/0000-0003-0385-8726)
- Slim Fourati (ORCID: https://orcid.org/0000-0001-6609-7587)
- Florence Herr (ORCID: https://orcid.org/0000-0003-1054-8611)
- Houria Hendel‐Chavez
- Marie-Ghislaine de Goër de Herve
Institutions
- Inserm (FR)
- Université Paris-Saclay (FR)
- Institut Gustave Roussy (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Centre hospitalier universitaire d'Orléans (FR)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- Transplantation
- Published
- 2025-06-17
- DOI
- https://doi.org/10.1097/tp.0000000000005448
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00