Association between pace of biological aging and cancer and the modulating role of physical activity: a national cross-sectional study
The study supported the hypothesis by demonstrating a positive association between the DunedinPoAm-measured pace of biological aging and cancer risk and a modulating role of physical activity. Physically inactive individuals or participants over 65 years showed increased susceptibility to this association. These findings suggest that incorporating the DunedinPoAm-measured pace of biological aging into cancer screening strategies may benefit those with physically inactive lifestyles and older individuals. Whether physical activity can mitigate the increased risk of cancer in individuals with a faster pace of biological aging needs to be validated in further interventional cohort studies.
Authors
- Jingying Nong (ORCID: https://orcid.org/0000-0002-0682-2190)
- Yi Zhang (ORCID: https://orcid.org/0000-0002-2657-4876)
- Yu Wang (ORCID: https://orcid.org/0000-0002-8009-9076)
Institutions
- Renmin University of China (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13148-025-01912-1
- Citations
- 1
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Capital Health Research and Development of Special Fund