Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer

Our findings suggest that CLDN10B acts as a tumor suppressor, and its epigenetic regulation may represent a therapeutic target for RCC. Ultimately, understanding CLDN10B's regulation and function could provide new insights into renal cancer treatment.

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Publication Details

Journal
Clinical Epigenetics
Published
2025-06-16
DOI
https://doi.org/10.1186/s13148-025-01911-2
Citations
1
Primary Topic
Barrier Structure and Function Studies
Type
article
Field-Weighted Citation Impact
0.84

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article

Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer

Richard Volckmann, Jan Halbritter, Marek Bartkuhn, Andreas Hahn et al.
1 citations
Clinical Epigenetics
Barrier Structure and Function Studies
0.84
article

Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer

Richard Volckmann, Jan Halbritter, Marek Bartkuhn, Andreas Hahn, Antje Richter, Paula Silva, Nora Philipp, Silke Haerteis, Aline Koch, Oliver Roßbach, Reinhard Dammann, Dianne Groll, Denise Salzig, Johannes Graumann, Yufen Zhao, Witold Szymański, Sarah Arroyo Villora, Tara Procida‐Kowalski, Jan Koster, S. Maurer, Cornelia Sigges, Vivien Olanin, Vera Roetzer
article en
1 citations

Abstract

Our findings suggest that CLDN10B acts as a tumor suppressor, and its epigenetic regulation may represent a therapeutic target for RCC. Ultimately, understanding CLDN10B's regulation and function could provide new insights into renal cancer treatment.

Clinical EpigeneticsVol. 17(1)
Justus-Liebig-Universität Gießen (DE), Cardio-Pulmonary Institute (DE), Technische Hochschule Mittelhessen (DE), University of Regensburg (DE), Charité - Universitätsmedizin Berlin (DE), University of Amsterdam (NL)
Danish Cancer Society Research Center, Bundesministerium für Bildung und Forschung
Reduced inequalities
Openalex Percentile: Top 25%
Barrier Structure and Function Studies
0.84
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