Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer
Our findings suggest that CLDN10B acts as a tumor suppressor, and its epigenetic regulation may represent a therapeutic target for RCC. Ultimately, understanding CLDN10B's regulation and function could provide new insights into renal cancer treatment.
Authors
- Richard Volckmann (ORCID: https://orcid.org/0009-0009-4490-3096)
- Jan Halbritter (ORCID: https://orcid.org/0000-0002-1377-9880)
- Marek Bartkuhn (ORCID: https://orcid.org/0000-0001-6872-9082)
- Andreas Hahn (ORCID: https://orcid.org/0000-0003-0235-5211)
- Antje Richter
- Paula Silva (ORCID: https://orcid.org/0000-0003-2655-2949)
- Nora Philipp (ORCID: https://orcid.org/0000-0002-3918-7795)
- Silke Haerteis
- Aline Koch (ORCID: https://orcid.org/0000-0003-3536-5344)
- Oliver Roßbach (ORCID: https://orcid.org/0000-0002-1172-0359)
- Reinhard Dammann (ORCID: https://orcid.org/0000-0001-6407-1236)
- Dianne Groll (ORCID: https://orcid.org/0000-0001-6913-5710)
- Denise Salzig (ORCID: https://orcid.org/0000-0001-9266-1356)
- Johannes Graumann (ORCID: https://orcid.org/0000-0002-3015-5850)
- Yufen Zhao (ORCID: https://orcid.org/0000-0003-3560-435X)
- Witold Szymański (ORCID: https://orcid.org/0000-0002-1202-3299)
- Sarah Arroyo Villora (ORCID: https://orcid.org/0009-0003-6491-4637)
- Tara Procida‐Kowalski (ORCID: https://orcid.org/0009-0004-0527-100X)
- Jan Koster
- S. Maurer
- Cornelia Sigges
- Vivien Olanin
- Vera Roetzer
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Cardio-Pulmonary Institute (DE)
- Technische Hochschule Mittelhessen (DE)
- University of Regensburg (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Amsterdam (NL)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13148-025-01911-2
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Danish Cancer Society Research Center
- Bundesministerium für Bildung und Forschung