Clinical and analytical validation of a combined RNA and DNA exome assay across a large tumor cohort
This study provides practical validation guidelines for integrated RNA and DNA sequencing in clinical oncology. The combined assay enhances the detection of actionable alterations, thereby facilitating personalized treatment strategies for cancer patients.
Authors
- Anna Love (ORCID: https://orcid.org/0000-0003-4627-3138)
- Cagdas Tazearslan
- Polina Turova (ORCID: https://orcid.org/0000-0003-3472-7059)
- Leznath Kaneunyenye
- Noel English
- Samuel W. Andrewes
- Yaroslav Lozinsky (ORCID: https://orcid.org/0000-0002-7852-6075)
- Olesia Klimchuk
- Danielle Sookiasian (ORCID: https://orcid.org/0009-0000-5534-6066)
- Daria Shafranskaya (ORCID: https://orcid.org/0000-0001-8030-989X)
- Alexander Bagaev (ORCID: https://orcid.org/0000-0002-8680-854X)
- Brianna McKenna
- Jessica Brown (ORCID: https://orcid.org/0000-0002-9278-0598)
- Anastasiya Yudina
- Jochen K. Lennerz (ORCID: https://orcid.org/0000-0003-2434-4978)
- Ekaterina Nuzhdina (ORCID: https://orcid.org/0000-0002-4059-0901)
- Sergey Starikov (ORCID: https://orcid.org/0000-0002-9112-6033)
- Natalia Kuzkina
- Konstantin Chernyshov
- Svetlana Podsvirova (ORCID: https://orcid.org/0000-0003-0347-2233)
- Vitaly Segodin
- Dawn Fernandez (ORCID: https://orcid.org/0000-0003-1738-1754)
- Madison Chasse (ORCID: https://orcid.org/0009-0004-9831-8697)
- Aviva Feinberg
- Mary Abdou
- Alexander M. Sobolev
- Artur Baisangurov
- Kelley Lauziere
- Kirill Shaposhnikov
- А А Ефремов
- John Curran
- Gleb Khegai (ORCID: https://orcid.org/0009-0003-2505-3846)
Institutions
- Addgene (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1038/s43856-025-00934-3
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94