PRELIMINARY ANALYSIS OF SEPALS OF PHARMACOPOEIAL ROSEHIP SPECIES

The analysis of literary sources indicates the growing interest of researchers in the search for new sources of medicinal plant raw materials. In the Russian Federation, it is currently allowed to use such types of wild rose as May rosehip, acuminate rosehip, Daurian rosehip, Begger's rosehip, Fedchenko's rosehip, wrinkled rosehip and others, which are regulated by the FS standard.2.5.0106 "Rosehip fruits". According to the requirements of GF XV, whole raw materials, rosehip fruits, are cleaned of sepals, which are usually disposed of. The sepals are removed after the raw materials are dried. When processing rosehip fruits for the production of drugs such as Rosehip Oil, Carotolin, Rosehip Syrup, and Holosas, sepals accumulate in significant amounts as industrial waste. In the context of current trends in the processing of phytoprotection waste, which makes it possible to reduce the cost of drugs and create innovative products, it becomes relevant to study the chemical composition of these wastes and assess their potential use in pharmaceutical practice. The purpose of this work is to conduct a preliminary analysis of the composition of biologically active substances in the sepals of rosehip fruits and to assess the content of extractive substances and various groups of biologically active compounds. The authors quantified the content of extractive substances in the sepals of rosehip fruits of three species, the quantitative content of the sum of water-soluble polysaccharides (from 4.21 to 6.42), the sum of polyphenolic substances (from 6.19 to 7.76), the sum of organic acids (from 2.45 to 3.64), the sum of triterpene saponins (from 0.89 to 1.14). Despite the presence of a significant amount of valuable biologically active compounds in the raw materials, the sepals of rosehip fruits are currently classified as waste from the processing of pharmacopoeial raw materials and are subject to disposal. This situation highlights the need for in-depth research aimed at isolating and identifying individual active components contained in the sepals. In addition, an assessment of their pharmacological activity and potential therapeutic effects is required. Conducting such research can help open up new opportunities for the use of these raw materials in medical and pharmaceutical practice, which, in turn, will optimize the use of resources and develop innovative products based on previously ignored waste.