STUDY OF THE INFLUENCE OF MEDICAL AND SOCIAL FACTORS ON PREGNANCY AFTER THE USE OF ASSISTED REPRODUCTIVE TECHNOLOGIES

The study is devoted to the influence of medical and social factors on pregnancy after the use of assisted reproductive technologies (ART). A retrospective observational cohort study was conducted based on the ART Department of the State Budgetary Healthcare Institution "Dynasty Medical Center". Analytical and statistical methods were used. Data were collected retrospectively based on medical records for 5 years from 2000 to 2024 using a continuous method. Inclusion criteria for the main group (OG - 250 women): women with infertility, with a singleton pregnancy after a successful cycle of in vitro fertilization (IVF) using fresh sperm, which ended in an abortive outcome (non-viable pregnancy, miscarriage). Inclusion criteria for the control group (CG - 500 women): women with infertility, with a singleton pregnancy after a successful cycle of in vitro fertilization (IVF) using fresh sperm, which ended in childbirth. Exclusion criteria for both groups: use of donor oocytes or cryopreserved embryos, sperm. Results: the main risk factors for miscarriage after ART were identified: the presence of 5 or more chronic diseases in a woman; aggravated obstetric and gynecological history, habitual miscarriage, thrombophilia; the woman's age is over 36 years. The study emphasizes the need for careful medical support for women using assisted reproductive technologies, taking into account the identified risk factors.