Implications of the glymphatic system in the diagnostic and surgical workup of normal pressure hydrocephalus
DTI-ALPS, reflecting the GS function, resulted significantly lower in NPH patients than in healthy controls. Secondly, clinical improvement was associated with DTI-ALPS increase both after a positive response to TT and at long term follow-up following VPS surgery. Therefore, DTI-ALPS index could be a promising, rapid and non-invasive radiological biomarker for the pre-surgical evaluation and prognosis of NPH patients.
Authors
- Fabio Martino Doniselli (ORCID: https://orcid.org/0000-0002-2272-7855)
- Marco Schiariti (ORCID: https://orcid.org/0000-0001-5494-8292)
- Francesco Restelli (ORCID: https://orcid.org/0000-0002-3789-957X)
- Francesco Acerbi (ORCID: https://orcid.org/0000-0002-4063-3924)
- Riccardo Primavera (ORCID: https://orcid.org/0009-0008-3812-5358)
- Alessandro Gans (ORCID: https://orcid.org/0000-0002-6222-8479)
- Marina Grisoli (ORCID: https://orcid.org/0000-0002-7663-446X)
- Paolo Ferroli (ORCID: https://orcid.org/0000-0002-8744-8857)
- Domenico Aquino (ORCID: https://orcid.org/0000-0002-1289-9573)
- Veronica Redaelli (ORCID: https://orcid.org/0000-0001-6884-112X)
- Morgan Broggi (ORCID: https://orcid.org/0000-0001-8818-1317)
- Giuseppe Di Fede (ORCID: https://orcid.org/0000-0003-3537-6713)
- Edoardo Maria Barbieri
Institutions
- University of Pisa (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1007/s10072-025-08308-2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca