The utility of 68Ga-DOTATATE and 18F-FDG PET/CT in predicting the response to tyrosine kinase inhibitors in patients with advanced medullary thyroid cancer
In a small cohort of MTC patients, MTV and TLA on <sup>18</sup>F-FDG PET/CT were associated with the structural response of TKI treatment, suggesting their potential utility in identifying patients who are likely to respond significantly. In contrast, TKI response showed no correlation with uptake on <sup>68</sup>Ga-DOTATATE PET/CT.
Authors
- Rhonda Siddall
- Schelto Kruijff
- Alexander Papachristos (ORCID: https://orcid.org/0000-0003-4634-5963)
- Matti L. Gild (ORCID: https://orcid.org/0000-0002-6670-2254)
- James W. McNeil
- Anthony Robert Glover (ORCID: https://orcid.org/0000-0003-0762-0977)
- Jeremy Hoang
- Mark Sywak
- Eline C. Jager (ORCID: https://orcid.org/0000-0001-8296-6703)
- Ayanthi Wijewardene (ORCID: https://orcid.org/0000-0001-7868-1545)
- Martyn Bullock (ORCID: https://orcid.org/0000-0002-3740-5509)
- Roderick John Clifton-Bligh (ORCID: https://orcid.org/0000-0002-1545-0368)
- Thera P. Links (ORCID: https://orcid.org/0000-0001-5327-1718)
- Adrienne H. Brouwers (ORCID: https://orcid.org/0000-0003-2698-1516)
- Bruce Robinson (ORCID: https://orcid.org/0000-0002-5281-7923)
- Lyndal Tacon
- Venessa Tsang
- Geoffrey Schembri (ORCID: https://orcid.org/0000-0002-6814-3636)
- Stan B. Sidhu
Institutions
- The University of Sydney (AU)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Royal North Shore Hospital (AU)
- Karolinska Institutet (SE)
Publication Details
- Journal
- Thyroid Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13044-025-00250-x
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00