Axillary adipose tissue–derived lymphatic endothelial cells exhibit distinct transcriptomic signatures reflecting lymphatic invasion status in breast cancer
The ability to isolate and characterize patient-derived LECs from mammary adipose tissue offers new insights into the cellular mechanisms underlying breast cancer metastasis. Significant gene expression variability related to disease state highlights the potential of these cells as biomarkers and therapeutic targets. This study emphasizes the importance of using patient-derived cells to accurately assess the tumor microenvironment, potentially leading to more personalized therapeutic approaches.
Authors
- Reo Maruyama (ORCID: https://orcid.org/0000-0001-7166-5964)
- Liying Yang (ORCID: https://orcid.org/0000-0002-4336-9014)
- Miwa Tanaka (ORCID: https://orcid.org/0000-0003-4934-3787)
- Jun Suzuka (ORCID: https://orcid.org/0000-0001-6021-4156)
- Tomo Osako (ORCID: https://orcid.org/0000-0001-9250-4035)
- Yuka Inoue
- Takehiko Sakai (ORCID: https://orcid.org/0000-0002-4982-951X)
- Asumi Iesato (ORCID: https://orcid.org/0000-0002-5277-0678)
- Kohei Kumegawa (ORCID: https://orcid.org/0000-0003-3732-2874)
- Shinji Ohno (ORCID: https://orcid.org/0000-0003-2093-3353)
- Natsue Uehiro (ORCID: https://orcid.org/0000-0002-6940-448X)
- Kazuyo Yoshida
- Takayuki Ueno (ORCID: https://orcid.org/0000-0002-9080-9377)
- Kana Sakiyama
- Kazutaka Otsuji (ORCID: https://orcid.org/0000-0002-5688-5536)
- Nami Yamashita (ORCID: https://orcid.org/0000-0001-7182-1090)
- Ai Tsuchiya
- Tetsuyo Maeda (ORCID: https://orcid.org/0009-0006-8015-4932)
- Yōko Takahashi (ORCID: https://orcid.org/0000-0002-6235-4184)
- Tetsuo Noda
- Sumito Saeki
Institutions
- Japanese Foundation For Cancer Research (JP)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1186/s13058-025-02067-w
- Citations
- 3
- Primary Topic
- Lymphatic System and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Japan Agency for Medical Research and Development
- Kowa Company
- Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care
- Kowa Life Science Foundation
- Japan Society for the Promotion of Science