Aerobic exercise pretreatment mitigates acute lung injury through metabolic reprogramming, anti-inflammatory modulation, and 6-keto-prostaglandin F1α regulation
AE pretreatment confers protection against ALI by orchestrating metabolic reprogramming to enhance anti-inflammatory responses. AE pretreatment attenuates LPS-induced ALI by reprogramming linoleic acid and arachidonic acid metabolism, thereby suppressing 6-keto-PGF1α biosynthesis. Pharmacological inhibition of 6-keto-PGF1α significantly alleviated ALI severity and mortality. These findings highlight AE as a preventive strategy and identify 6-keto-PGF1α as a therapeutic target for inflammatory lung injury.
Authors
- Xishuai Wang (ORCID: https://orcid.org/0000-0001-5972-0676)
- Shaojun Nong
- Depeng Dong
- Qingshan Zheng (ORCID: https://orcid.org/0000-0001-6235-8137)
- Chao Yi
- Weina Niu
- Lichang Yang
- Cong Liu (ORCID: https://orcid.org/0000-0002-2145-5034)
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-6351-8689)
- Song Li (ORCID: https://orcid.org/0000-0003-4463-733X)
- Xiliang Kong
- Zhao Congcong
- Xin Jin (ORCID: https://orcid.org/0000-0003-2211-2006)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-8557-297X)
- Fengtao Jiang (ORCID: https://orcid.org/0000-0003-3447-5576)
- Shanshan Cai (ORCID: https://orcid.org/0000-0003-0117-5171)
- Yuehui Zhou
- Yang Lv
- Di Wu (ORCID: https://orcid.org/0000-0001-8105-2205)
- Lunan Zhao
- Jie Wei (ORCID: https://orcid.org/0009-0000-7600-8779)
- Zhuo Sun (ORCID: https://orcid.org/0009-0008-6068-0067)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Qilu University of Technology (CN)
- Guangxi Medical University (CN)
- Jilin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qufu Normal University (CN)
- Beijing Normal University (CN)
- National Academy of Education (US)
- Suzhou Institute of Systems Medicine (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Baise University (CN)
- Nanjing Jiangning Hospital (CN)
- Lancaster University (GB)
- Northwest Normal University (CN)
- Nanjing Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.06.024
- Citations
- 1
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.52