Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments
These results supported the hypothesis that age-dependent upregulation of Nr4a1 attenuated PI3K/AKT/GSK-3β pathway, leading to tau hyperphosphorylation and cognitive decline. Nr4a1 may represent a promising therapeutic target for mitigating age-related cognitive impairments.
Authors
- Yong Luo (ORCID: https://orcid.org/0000-0002-4689-536X)
- Lei Ling (ORCID: https://orcid.org/0000-0001-6316-2128)
- Yuran Gui
- Wensheng Li (ORCID: https://orcid.org/0000-0003-4160-9317)
- Jian‐Zhi Wang (ORCID: https://orcid.org/0009-0000-2068-6749)
- Xiaochuan Wang (ORCID: https://orcid.org/0000-0001-8207-0042)
- Qian Guo (ORCID: https://orcid.org/0000-0003-2551-6882)
- Rong Liu (ORCID: https://orcid.org/0000-0003-2853-1949)
- Yi Zhao (ORCID: https://orcid.org/0000-0003-4593-8353)
- Zhendong Xu (ORCID: https://orcid.org/0000-0003-4343-8080)
- Yiyu Cheng (ORCID: https://orcid.org/0000-0003-1423-162X)
- Honglian Li
- Gang Wu
Institutions
- Nantong University (CN)
- Jianghan University (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-16
- DOI
- https://doi.org/10.1016/j.jare.2025.06.033
- Citations
- 1
- Primary Topic
- Nuclear Receptors and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.91
Funders
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality