4-Aryl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-1-phenyl-1H-pyrazoles: Synthesis, Characterization, and Biological Activity

The title compounds were synthesized through the reaction of the corresponding (E)-3-aryl-1-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-en-1-ones with phenylhydrazine in glacial acetic acid. Their structure was confirmed by elemental analysis, infrared spectroscopy, 1H and 13C NMR, and mass spectrometry The new pyrazole derivatives were evaluated for their antibacterial activity against a range of microbial species, including Escherichia coli, Pseudomonas aeruginosa (Gram-negative), Staphylococcus aureus, Bacillus subtilis (Gram-positive), and Candida albicans. The synthesized compounds also demonstrated superior in vitro anticancer activity compared to doxorubicin.