Simulation and Optimization of a Low-Voltage Microseparator Based on Dielectrophoresis Forces for Blood Cell Separation

The objective of this investigation is to develop optimization approaches for the separation of platelets from red blood cells (RBCs). A novel microfluidic device with triangular electrodes operating at a low voltage of 1.5 V and a frequency of 100 kHz is proposed for the separation of platelets and RBCs using dielectrophoresis (DEP) force. Using of a low voltage ensures the preservation of the viability of biological cells, which is a crucial factor for medical applications. Through a comparative investigation utilizing the finite element method, the impact of varying electrode dimensions on the effective separation of particles is demonstrated. Profiles of electric field, pressure, and DEP force acting on two particles are presented through simulation.