Leptomeningeal hemangioblastoma: illustrative case
After resection, hemangioblastoma recurrence with leptomeningeal spread is a rare but dangerous possible complication. Management is complex, yet a combination of pan-CNS radiation therapy, targeted resection, and belzutifan (a small-molecule inhibitor that selectively targets and blocks the function of HIF-2α) may represent an effective treatment combination. https://thejns.org/doi/10.3171/CASE25204.
Authors
- Scott Lindhorst (ORCID: https://orcid.org/0000-0002-1585-4450)
- Tiffany R. Baker
- Charlotte Rivers
- Alicia Zukas (ORCID: https://orcid.org/0000-0002-4731-0239)
- Ben A. Strickland (ORCID: https://orcid.org/0000-0002-4620-9542)
- Aaron L. Miller (ORCID: https://orcid.org/0000-0002-2693-4640)
- William A. Vandergrift (ORCID: https://orcid.org/0000-0002-6099-3118)
- Noah Nawabi
- Joshua M. Venegas (ORCID: https://orcid.org/0009-0007-6926-1339)
Institutions
- Medical University of South Carolina (US)
Publication Details
- Journal
- Journal of Neurosurgery Case Lessons
- Published
- 2025-06-16
- DOI
- https://doi.org/10.3171/case25204
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00