PELTOGYNOIDS FROM Peltogyne catingae DUCKE AND THEIR ANTIFUNGAL POTENTIAL AGAINST Sporothrix spp.

Peltogyne catingae is an Amazonian species with a purple heartwood that is highly resistant to attacks by xylophagous organisms. This antimicrobial property may be related to modified flavonoids known as peltogynoids. This study analyzed the composition of peltogynoids extracted from P. catingae wood residues using high performance liquid chromatography-mass spectrometry (HPLC-MS) and nuclear magnetic resonance (NMR). Additionally, their antifungal activities were assessed against fungi isolated from Sporothrix schenckii (ATCC 32286) and Sporothrix brasiliensis (clinical isolate), which cause feline sporotrichosis. The isomers (+)-peltogynol (1) and (+)-mopanol (2) and their respective epimers (+)-peltogynol B (3) and (+)-mopanol B (4) were identified. The mixture of peltogynoids 1-4 showed promising results as a fungicidal agent against S. schenckii (MIC 31.25 µg mL–1) and a fungistatic effect against S. brasiliensis (MIC 62.50 µg mL–1). The 1D and 2D NMR spectroscopic results of epimers 3 and 4 are described here for the first time. The peltogynoids identified in this study are candidates for antifungals for the treatment of feline sporotrichosis.